1. Prolactin stimulates receptor sites on alveolar cells; colostrum present from 16 weeks gestation.
2. Progesterone stimulates lobuloalveolar growth while suppressing secretory activity.
3. Placental expulsion is followed by abrupt decline In HPL, oestrogen and progesterone.
4. Prolactin levels increase without progesterone.
5. Shared afferent feedback from nipple to hypothalamus activates both oxytocin and prolactin release.
6. Autocrine control takes over with full secretion.
7. Feedback inhibitors of lactation, aided by serotonin and dopamine signaling, control production. Keeping the breasts empty accelerates the natural autonomous process.
8. Oxytocin permeates mothering areas of brain as well as myoepithelial cells surrounding alveoli.
9. Serotonin, the neurotransmitter in every alveolus manages PTHrP control of Ca and P in milk and furthers optimal bone density resetting in the mother.