PTHrP expression results from a local serotonin signaling system and is highly induced in response to alveolar dilatation due to milk secretion and provides export of large amounts of calcium and phosphorous. There is a four-fold greater calcium loss during 6 months lactation than whole pregnancy.
American Journal Physiol Endocrinol Metab 2012,302 E1009-E1015 Hernandez L et al.
Formula does not provide physiological protection for mother’s calcium loss during pregnancy leading to a 50% increased risk of femur neck fracture in post menopausal women who have formula fed.
